CB2 receptor antibody signal specificity: correlations with the use of partial CB2-knockout mice and anti-rat CB2 receptor antibodies
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چکیده
منابع مشابه
Validating Antibodies to the Cannabinoid CB2 Receptor
The problem of antibody reliability in research has now reached the point where many journals reject any work that lacks adequate controls for antibody validation. Despite this, it is still common for researchers to rely on positive controls and only minimal negative controls (such as blocking peptide controls). Using careful cross-comparisons between antibody labeling and other labeling techni...
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Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino-thalamic pathway and exerts a modulatory action on axon guidance. These effects are specific to CB2R since no changes were observed in mice where th...
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Evidence has emerged suggesting a role for the cannabinoid CB2 receptor in immune cell motility. This provides a rationale for a novel and generalized immunoregulatory role for cannabinoid CB2 receptor-specific compounds. In support of this possibility, we will review the biology of a class of cannabinoid CB2 receptor-specific inverse agonist, the triaryl bis-sulfones. We will show that one can...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2018
ISSN: 1671-4083,1745-7254
DOI: 10.1038/s41401-018-0037-3